ISSAQUAH, WASH. - Jan. 4, 2000 - Massachusetts Institute of Technology (MIT) biologists will develop a multiple-mode microscopy system with Applied Precision Inc. and Nikon Inc. that will advance the understanding of cellular behavior.
The newly-developed system will integrate live-cell GFP imaging applications from Applied Precision's DeltaVision® Restoration Microscope System with Nikon's PCM2000® laser scanning confocal system into a single, cost-effective and highly productive imaging system. This customized imaging system will enable MIT researchers, led by Dr. Martha Constantine-Paton and Dr. Peter Sorger, to capture two- and three-dimensional live-cell images using light and laser-based imaging schemes, and restorative and confocal microscopy, on a single integrated platform.
"We are looking forward to working with Dr. Constantine-Paton and Dr. Sorger to push the limits of technology even further," said Rich Fisler, Applied Precision's biotechnology product line manager. "Our precision technology and engineering expertise - combined with specifications from the MIT team - will result in a superior product to help scientists advance the understanding of cellular behavior."
The MIT team will use the multiple-mode microscopy system to:
- Further understand the basic biology of cancer and cell proliferation
- Image live brain and neuronal tissue to determine the molecular basis of learning and memor
- Develop image informatics as a tool for drug discovery in the pharmaceutical industries
"The combination of confocal and restoration microscopy into one workstation will provide us with a state-of-the-art imaging tool to get quantitative, three-dimensional data from living and fixed cells and tissue," said Dr. Sorger, assistant professor of biology at MIT. "It will be very rewarding for us to have such direct input into the production of imaging tools."
About DeltaVision
Technologies for Applied Precision's DeltaVision Restoration Microscopy System stem from a unique blend of mechanics, electronics and software, dubbed "precisionware." The DeltaVision System integrates a highly optimized fluorescence microscope, high precision XYZ stage and control, custom optical filters with complete light path management, multi-site functionality and 3D image processing, interaction and display. DeltaVision provides fast, highly accurate handling of live-cell, multiple-wavelength and multiple-dimension specimen imaging at the highest possible resolutions while providing quantifiable, validated data.
About Applied Precision
Applied Precision leads the high-tech industry in the development and manufacture of "precisionware." Precisionware represents the unique convergence of software, electronics and mechanics into specialized product solutions for biotechnology research, semiconductor metrology test, photonics, digital flow control and micropositioning.
Applied Precision was founded in 1986 by engineers from three disciplines - mechanics (John Stewart), electronics (Ron Seubert) and physics (Don Snow). API's three founders continue to play active roles in the company. The company now employs over 100 engineers, technicians, managers, and sales and marketing professionals at its Seattle-area headquarters and its European sales and service center. Applied Precision's biotechnology product line is also available at SciQuest.com.
For additional information on the company and its products, contact Applied Precision at (425) 557-1000.
About Nikon Inc.
Nikon Inc. is the U.S. distributor of world-renowned Nikon microscopes and imaging systems for biosciences, the Nikon professional 35mm photography system, compact automatic 35mm cameras and Advanced Photo System cameras, digital still cameras, the Nikon speedlight system, interchangeable Nikkor lenses, Nikonos underwater photographic systems, Nikon film scanners, Nikon sports and recreational optics, Nikon industrial inspection and measuring systems, Nikon Eyewear, and Nikon surveying and ophthalmic instruments.
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